Invention Grant
- Patent Title: EphA5-binding antibodies and uses thereof and selection of phage-displayed accessible recombinant targeted antibodies
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Application No.: US16333898Application Date: 2017-09-21
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Publication No.: US11254751B2Publication Date: 2022-02-22
- Inventor: Renata Pasqualini , Wadih Arap , Fernanda Iamassaki Staquicini , Fortunato Ferrara , Sara D'Angelo , Andrew R. M. Bradbury
- Applicant: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- Applicant Address: US NJ New Brunswick
- Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- Current Assignee: RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY
- Current Assignee Address: US NJ New Brunswick
- Agency: Saul Ewing Arnstein & Lehr LLP
- Agent Domingos J. Silva
- International Application: PCT/US2017/052661 WO 20170921
- International Announcement: WO2018/057703 WO 20180329
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; C07K16/30 ; A61P35/00 ; G01N33/574 ; C07K16/18 ; A61K47/68 ; A61K38/07 ; C12N15/10 ; A61K39/00
Abstract:
Isolated or recombinant Eph A5 or GRP78 targeting antibodies are provided. In some cases, antibodies of the embodiments can be used for the detection, diagnosis and/or therapeutic treatment of human diseases, such as cancer. A method of rapidly identifying antibodies or antibody fragments for the treatment of cancer using a combination of in vitro and in vivo methodologies is also provided.
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