Invention Grant
- Patent Title: Compositions and methods for the selective detection of tumor-derived viral DNA
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Application No.: US17203068Application Date: 2021-03-16
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Publication No.: US11254989B2Publication Date: 2022-02-22
- Inventor: Gaorav Gupta , Bhishamjit S. Chera , Sunil Kumar
- Applicant: The University of North Carolina at Chapel Hill
- Applicant Address: US NC Chapel Hill
- Assignee: The University of North Carolina at Chapel Hill
- Current Assignee: The University of North Carolina at Chapel Hill
- Current Assignee Address: US NC Chapel Hill
- Agency: Thomas | Horstemeyer, LLP
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C12Q1/6888 ; C12Q1/70 ; C12Q1/686 ; C12Q1/6853
Abstract:
The present disclosure provides methods and compositions of modified oligonucleotide primer and probe combinations, structurally modified with locked nucleic acids, quenchers, and dyes, effective to detect tumor-derived Human Papilloma Virus (HPV) and tumor-derived Epstein-Barr virus (EBV) and, especially, to distinguish viral DNA derived from tumors from viral DNA derived from infectious viral particles.
Public/Granted literature
- US20210285060A1 COMPOSITIONS AND METHODS FOR THE SELECTIVE DETECTION OF TUMOR-DERIVED VIRAL DNA Public/Granted day:2021-09-16
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