A real-time route determination system includes one or more communication devices in signal communication with a route server system. Each communication device is configured to receive one or both of vehicle data and user data to determine a stress-level based on one or both of the vehicle data and the user data. The route server system is configured to determine at least one navigation route in real-time based in part on the stress-level, and to output a route signal indicative of the at least one navigation route. The communication device displays a graphical map including a graphical route displaying the at least one navigation route.