Mobile high density read chambers are provided for scanning a plurality of RFID tagged items. Such chambers may include an enclosure with an interior defined by upper and lower surfaces, with a sidewall extending therebetween. An access (such as a door) may be associated with the sidewall, with the access being at least partially opened to access the interior of the enclosure from an outside location. The chamber further includes an RFID reader having at least one antenna positioned within the interior of the enclosure to emit a scanning signal within the interior of the enclosure. A base supports the enclosure, with at least one movement member supporting the base and configured to engage a ground surface for transport of the mobile high density read chamber. The movement member may comprise one or more wheels, ball casters, low-friction sliders, or rollers, for example.