Embodiments are generally directed to GPU mixed primitive topology type processing. An embodiment of an apparatus includes one or more processor cores; and a memory to store data for graphics processing, wherein the one or more processing cores are to generate in the memory a vertex buffer to store vertex data for a mesh to be rendered and an index buffer to index the vertex data stored in the vertex buffer, the index buffer being structured to include index data for multiple primitive topology types. The one or more processor cores are to process the index data for the plurality of primitive topology types from the index buffer and fetch vertex data from the vertex buffer; and are to set up each primitive topology type of the plurality of primitive topology types for processing in a single draw operation.