Various methods and systems are provided for scatter correction in nuclear medicine imaging systems. In one embodiment, a method for NM imaging comprises acquiring, with a plurality of detectors, imaging data separated into a high energy window and a low energy window, removing photopeak photons from the imaging data in the low energy window to obtain a corrected scatter distribution, correcting the imaging data based on the corrected scatter distribution, and outputting a scatter-corrected image reconstructed from the corrected imaging data. In this way, fast and accurate scatter correction for CZT-based gamma cameras may be performed, and image quality as well as quantitative accuracy may be increased.