A system for carrying a load at a controlled temperature includes a drone structure having a motor that handles the drone structure, an energy unit that delivers electric energy, and a control unit. The drone structure also includes a thermal container having an insulating casing with at least one layer of heat-insulating material, an inner temperature sensor that measures a value of temperature Tint internal to the insulating casing, an outer temperature sensor configured to measure a value of temperature Text external to the insulating casing, and a thermal unit arranged to adjust or keep constant the value of temperature Tint. The control unit is adapted to carry out an acquisition of a flight mission comprising a landing position of the drone structure, a time limit tmax to reach the landing position and a condition on the values of the temperature Tint to keep during the flight mission.