The present invention provides a pixel arrangement structure, a vapor deposition mask and an irregular-shaped display screen. The pixel arrangement structure is used for irregular-shaped display of an irregular-shaped display screen, the pixel arrangement structure is provided with several rows and/or several columns of pixel display units, wherein neighboring rows and/or neighboring columns of the pixel display units are arranged in parallel within an irregular-shaped display region (105). By arranging the pixel display units within the irregular-shaped display region (105) in such a way that the neighboring rows and/or neighboring columns of the pixel display units are parallel rows or columns, a confusion phenomenon at the interface between an irregular-shaped display region (105) and a non-display region (107) on an edge of the irregular-shaped display region (105) can be eliminated.