Invention Grant
- Patent Title: Peptides and method for treatment of cardiac arrest
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Application No.: US16895161Application Date: 2020-06-08
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Publication No.: US11260105B2Publication Date: 2022-03-01
- Inventor: Terry Vanden Hoek , Xiangdong Zhu , Jing Li
- Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Applicant Address: US IL Urbana
- Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
- Current Assignee Address: US IL Urbana
- Agency: Licata & Tyrrell P.C.
- Main IPC: A61K38/17
- IPC: A61K38/17 ; G01N33/68 ; A61P9/04 ; A61K31/455 ; C40B40/08 ; C07K16/00 ; C12N5/10 ; C12N9/16 ; C12N9/12
Abstract:
Modified peptides based on C-terminal PDZ binding domains of PTEN and PHLPP, or PDK1 interacting fragment of PKN2 are described as are methods of using the modified peptides for blocking the activity of PTEN, PHLPP and PKN2 and treating sudden cardiac arrest. A method for guiding treatment of cardiac arrest based on sorbitol or taurine levels is also provided.
Public/Granted literature
- US20200297813A1 Peptides and Method for Treatment of Cardiac Arrest Public/Granted day:2020-09-24
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