A catheter for vascular insertion, including a catheter body defining a first lumen and a second lumen, and including a distal region. The distal region may include a first distal opening in fluid communication with the first lumen, and a second distal opening in fluid communication with the second lumen. The distal region may also include a first lateral opening defined by the catheter body and in fluid communication with the first lumen, and a second lateral opening defined by the catheter body and in fluid communication with the second lumen. One or both of the first and second lateral openings may be defined by an angle cross-cut through an outer perimeter of the catheter body.