A Negative Pressure Wound Therapy (NPWT) dressing having a sealing layer on a non-wound interfacing surface. Such a sealed surface eases application and reduces the risk of a loss of seal once applied to a patient. Associated adaptors and couplers, which may be universal couplers, allow for simplified use of the disclosed and existing dressings. An optional pressure regulator unit may use existing wall suction available in medical facilities; it may interface with a transportation unit. Embodiments of the regulation unit provide for various monitoring, operation and alarming features that may be accessed using mobile wireless, wireless LAN, and internet based connectivity approaches.