Invention Grant
- Patent Title: Activators of autophagic flux and phospholipase d and clearance of protein aggregates including tau and treatment of proteinopathies
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Application No.: US16818388Application Date: 2020-03-13
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Publication No.: US11261199B2Publication Date: 2022-03-01
- Inventor: Kirsten Alison Rinderspacher , Wai Yu , Karen Duff , Donald Landry , Shi-Xian Deng
- Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK , NY STATE PSYCHIATRIC INSTITUTE
- Applicant Address: US NY New York; US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK,NY STATE PSYCHIATRIC INSTITUTE
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK,NY STATE PSYCHIATRIC INSTITUTE
- Current Assignee Address: US NY New York; US NY New York
- Agency: Venable LLP
- Main IPC: C07D513/04
- IPC: C07D513/04 ; C07D403/12 ; C07D405/12 ; C07D239/86 ; C07D239/93 ; C07D239/94 ; C07D471/04 ; C07D491/04 ; C07D495/04 ; A61K31/517 ; C07D217/22 ; C07D239/88 ; C07D401/12 ; C07D491/048 ; A61P25/28
Abstract:
The present application discloses compounds which are activators of autophagic flux and pharmaceutical compositions comprising said activators. It further discloses use of said compounds and pharmaceutical compositions in the treatment of neurodegenerative diseases, particularly proteinopathies and tauopathies such as Alzheimer's disease. It further discloses methods of enhancing autophagic flux.
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