Invention Grant
- Patent Title: TRNA synthetase inhibitors
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Application No.: US16961516Application Date: 2019-01-11
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Publication No.: US11261201B2Publication Date: 2022-03-01
- Inventor: Daniel E. Kahne , Vadim Baidin
- Applicant: President and Fellows of Harvard College
- Applicant Address: US MA Cambridge
- Assignee: President and Fellows of Harvard College
- Current Assignee: President and Fellows of Harvard College
- Current Assignee Address: US MA Cambridge
- Agency: Foley Hoag LLP
- International Application: PCT/US2019/013305 WO 20190111
- International Announcement: WO2019/140265 WO 20190718
- Main IPC: C07F5/02
- IPC: C07F5/02 ; A61P31/04 ; C07C211/27 ; C07C211/40 ; C07C215/28 ; C07D209/04 ; C07D213/38 ; C07D213/643 ; C07D215/06 ; C07D215/12 ; C07D221/04 ; C07D221/20 ; C07D231/12 ; C07D231/56 ; C07D239/26 ; C07D239/34 ; C07D261/08 ; C07D267/10 ; C07D295/13 ; C07D307/14 ; C07D307/79 ; C07D307/87 ; C07D309/04 ; C07D311/74 ; C07D317/58 ; C07D319/08 ; C07D327/06 ; C07D471/04 ; C07D471/08 ; C07D493/08 ; C07D495/04 ; C07D498/08
Abstract:
Disclosed herein are secondary amine compounds that inhibit tRNA synthetase. The compounds of the invention are useful in inhibiting tRNA synthetase in Gram-negative bacteria and are useful in killing Gram-negative bacteria. The secondary amine compounds of the invention are also useful in the treatment of tuberculosis.
Public/Granted literature
- US20210053997A1 TRNA SYNTHETASE INHIBITORS Public/Granted day:2021-02-25
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