Invention Grant
- Patent Title: Glycosylated antitumor ether lipids as novel cancer stem cell cytotoxic agents
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Application No.: US14377551Application Date: 2013-02-08
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Publication No.: US11261210B2Publication Date: 2022-03-01
- Inventor: Gilbert Arthur , Frank Schweizer , Pranati Samadder , Yaozu Xu
- Applicant: UNIVERSITY OF MANITOBA
- Applicant Address: CA Winnipeg
- Assignee: UNIVERSITY OF MANITOBA
- Current Assignee: UNIVERSITY OF MANITOBA
- Current Assignee Address: CA Winnipeg
- Agency: Ade + Company Inc.
- Agent Michael R. Williams; Ryan W. Dupuis
- International Application: PCT/CA2013/050105 WO 20130208
- International Announcement: WO2013/116949 WO 20130815
- Main IPC: C07H15/14
- IPC: C07H15/14 ; A61K31/7028 ; A61P35/00 ; A61K31/7032 ; C07H15/04 ; C07H7/02
Abstract:
Glycosylated antitumor ether lipids (GAELs) are effective cytotoxic agents against cancer stem cells. Furthermore, combining GAELs which kill cells by a caspase-independent pathway with agents that kill cells by apoptosis will lead to elimination of the differentiated tumor cells and the undifferentiated cancer stem cells leading to an elimination of the tumor and preventing recurrence.
Public/Granted literature
- US20150011486A1 GLYCOSYLATED ANTITUMOR ETHER LIPIDS AS NOVEL CANCER STEM CELL CYTOTOXIC AGENTS Public/Granted day:2015-01-08
Information query
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