Invention Grant
- Patent Title: Bicyclic peptide ligand specific for CD137
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Application No.: US16636105Application Date: 2018-08-03
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Publication No.: US11261214B2Publication Date: 2022-03-01
- Inventor: Liuhong Chen , Rachid Lani , Kevin McDonnell , Gemma Mudd , Peter Park
- Applicant: BicycleTx Limited
- Applicant Address: GB Cambridge
- Assignee: BicycleTx Limited
- Current Assignee: BicycleTx Limited
- Current Assignee Address: GB Cambridge
- Agency: Dechert LLP
- Agent Andrea L. C. Reid; Gang Wang
- Priority: GB1712589 20170804,GB1802934 20180223,GB1805850 20180409
- International Application: PCT/GB2018/052222 WO 20180803
- International Announcement: WO2019/025811 WO 20190207
- Main IPC: C07K7/64
- IPC: C07K7/64 ; A61K47/64 ; A61K38/00

Abstract:
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of CD137. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by CD137.
Public/Granted literature
- US20200255477A1 BICYCLIC PEPTIDE LIGAND SPECIFIC FOR CD137 Public/Granted day:2020-08-13
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