- Patent Title: Modified pigment epithelium-derived factor (PEDF) peptides and uses thereof for treating neovascular diseases, inflammatory diseases, cancer, and for cytoprotection
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Application No.: US16123863Application Date: 2018-09-06
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Publication No.: US11261237B2Publication Date: 2022-03-01
- Inventor: Jack Henkin , Olga Volpert , Serguei Vinogradov , Ignacio Melgar-Asensio
- Applicant: Northwestern University , Board of Regents of the University of Nebraska
- Applicant Address: US IL Evanston; US NE Lincoln
- Assignee: Northwestern University,Board of Regents of the University of Nebraska
- Current Assignee: Northwestern University,Board of Regents of the University of Nebraska
- Current Assignee Address: US IL Evanston; US NE Lincoln
- Agency: Casimir Jones SC
- Agent David W. Staple
- Main IPC: C07K14/81
- IPC: C07K14/81 ; A61K47/69 ; C07K7/06 ; C07K19/00 ; A61K47/61 ; A61K47/54 ; A61K47/55 ; A61K47/64 ; A61K38/00
Abstract:
Disclosed are modified pigment epithelium-derived factor (PEDF) peptides, particulate carrier prodrugs thereof, and pharmaceutical compositions comprising the peptides or particulate carrier prodrugs. The peptides, particulate carrier prodrugs, and pharmaceutical compositions may be used to treat diseases and disorders that are amenable to treatment with anti-angiogenic agents, anti-tumorigenic agents, anti-fibrotic agents, chemotherapy-protecting agents, and immune stimulating agents.
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