Invention Grant
- Patent Title: Fixed-bed bioreactor with constant-flow pump / tubing system
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Application No.: US15579208Application Date: 2017-04-03
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Publication No.: US11261416B2Publication Date: 2022-03-01
- Inventor: Piia Kristiina Valonen , Hanna P. Lesch , Eva Kristiina Rasanen , Tarja Hannele Tuunanen , Minna Kristiina Karhinen , Seppo Yla-Herttuala
- Applicant: Trizell Ltd.
- Applicant Address: GB Chinnor
- Assignee: Trizell Ltd.
- Current Assignee: Trizell Ltd.
- Current Assignee Address: GB Chinnor
- Agency: Choate, Hall & Stewart LLP
- Agent Rolando Medina
- International Application: PCT/US2017/025681 WO 20170403
- International Announcement: WO2017/180341 WO 20171019
- Main IPC: C12M1/00
- IPC: C12M1/00 ; C12M1/02 ; C12P21/02 ; C12M1/12 ; C12N15/86 ; C12M1/34 ; C07K14/005

Abstract:
We have modified a commercially-available adherent cell culture bioreactor in several ways to increase productivity of cultured cells, while decreasing contamination risk. We found that modifying a commercially-available adherent cell culture bioreactor to provide for slower cell culture medium flow unexpectedly and dramatically increases the productivity of the cultured adherent cells. We also developed a new sampling manifold configuration and new way of taking samples, to reduce contamination risk.
Public/Granted literature
- US20190031998A1 Fixed-Bed Bioreactor With Constant-Flow Pump / Tubing System Public/Granted day:2019-01-31
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