Invention Grant
- Patent Title: Enriched and expanded human cord blood stem cells for treatment of hematological disorders
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Application No.: US14892772Application Date: 2014-05-16
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Publication No.: US11261429B2Publication Date: 2022-03-01
- Inventor: Pratima Chaurasia , Ronald Hoffman
- Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Applicant Address: US NY New York
- Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee Address: US NY New York
- Agency: Fox Rothschild LLP
- International Application: PCT/US2014/038361 WO 20140516
- International Announcement: WO2014/189781 WO 20141127
- Main IPC: C12N5/0789
- IPC: C12N5/0789 ; G01N33/50 ; C12N5/0775
Abstract:
This invention relates to an enriched population of isolated and expanded human cord blood stem cells and a method of producing an enriched population of isolated and expanded human cord blood stem cells. The expanded human cord blood stem cells are CD34+, CD90+, CD1 84+, CD1 17+, CD49f+, ALDH+, CD45RA− and express pluripotency genes SOX2, OCT4, NANOG, and ZIC3. In one embodiment, the stem cells in the enriched population of the present invention are positive for aldehyde dehydrogenase activity (ALDH+). In addition, in one embodiment the expanded stem cells are nearly depleted of T cells and B cells and contain a limited number of monocytes (CD14). Also disclosed is a method of treating a subject for a hematological disorder using the stem cells of the present invention and a method of determining the effects of a compound on hematopoietic stem cells.
Public/Granted literature
- US20160097036A1 ENRICHED AND EXPANDED HUMAN CORD BLOOD STEM CELLS FOR TREATMENT OF HEMATOLOGICAL DISORDERS Public/Granted day:2016-04-07
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