Invention Grant
- Patent Title: Hematopoietic stem and progenitor cells derived from hemogenic endothelial cells
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Application No.: US16098359Application Date: 2017-05-03
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Publication No.: US11261430B2Publication Date: 2022-03-01
- Inventor: George Q. Daley , Ryohichi Sugimura
- Applicant: THE CHILDREN'S MEDICAL CENTER CORPORATION
- Applicant Address: US MA Boston
- Assignee: THE CHILDREN'S MEDICAL CENTER CORPORATION
- Current Assignee: THE CHILDREN'S MEDICAL CENTER CORPORATION
- Current Assignee Address: US MA Boston
- Agency: Nixon Peabody LLP
- Agent David S. Resnick; Teresa A. Ptashka
- International Application: PCT/US2017/030822 WO 20170503
- International Announcement: WO2017/192708 WO 20171109
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C12N5/02 ; C12N5/071 ; C07H21/04 ; C12N5/0789 ; A61K35/44 ; A61K35/28 ; C12N15/63
Abstract:
Embodiments herein relate to in vitro production methods of hematopoietic stem cell (HSC) and hematopoietic stem and progenitor cell (HSPC) that have long-term multilineage hematopoiesis potentials upon in vivo engraftment. The HSC and HSPCs are derived from pluripotent stem cells-derived hemogenic endothelia cells (HE).
Public/Granted literature
- US20190119643A1 HEMATOPOIETIC STEM AND PROGENITOR CELLS DERIVED FROM HEMOGENIC ENDOTHELIAL CELLS Public/Granted day:2019-04-25
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