Invention Grant
- Patent Title: Methods for producing preparations of recombinant AAV virions substantially free of empty capsids
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Application No.: US16538664Application Date: 2019-08-12
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Publication No.: US11261463B2Publication Date: 2022-03-01
- Inventor: Guang Qu , John Fraser Wright
- Applicant: Genzyme Corporation
- Applicant Address: US MA Cambridge
- Assignee: Genzyme Corporation
- Current Assignee: Genzyme Corporation
- Current Assignee Address: US MA Cambridge
- Agency: Morrison & Foerster LLP
- Main IPC: C12N15/86
- IPC: C12N15/86 ; C12N7/00
Abstract:
Methods for separating AAV empty capsids from mixtures of AAV vector particles and AAV empty capsids are described. The methods use column chromatography techniques and provide for commercially viable levels of recombinant AAV virions.
Public/Granted literature
- US20200157566A1 METHODS FOR PRODUCING PREPARATIONS OF RECOMBINANT AAV VIRIONS SUBSTANTIALLY FREE OF EMPTY CAPSIDS Public/Granted day:2020-05-21
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