Invention Grant
- Patent Title: Nano-neurotoxicity bio-marker composition based on intracellular aggregates which are biomarkers of degenerative brain diseases
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Application No.: US16311161Application Date: 2017-05-12
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Publication No.: US11261475B2Publication Date: 2022-03-01
- Inventor: Tae Hwan Shin , Geetika Phukan , Man Jeong Paik , Hyeon-Seong Lee , Hyung-Jin Park , Da Yeon Lee , Gwang Lee
- Applicant: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
- Applicant Address: KR Suwon-si
- Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
- Current Assignee: AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
- Current Assignee Address: KR Suwon-si
- Agency: Revolution IP, PLLC
- Priority: KR10-2016-0076570 20160620
- International Application: PCT/KR2017/004948 WO 20170512
- International Announcement: WO2017/222180 WO 20171228
- Main IPC: C12Q1/02
- IPC: C12Q1/02 ; C12Q1/6883 ; C12Q1/6837 ; C12Q1/6881
Abstract:
A method of assessing neurotoxicity of nanoparticles, includes: preparing a tissue or cell sample of mammal exposed to the nanoparticles; analyzing at least one polyamine metabolite selected from the group consisting of putrescine, N1-acetylspermidine, N8-acetylspermidine, N1-acetylspermine and spermine in the sample; and comparing expression degree of the polyamine metabolite with that of a control.
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