A lock with a roller deadbolt includes a driving member having a first slot and a transverse slot. The driving member is connected to a first spring, a second spring and a positioning rod. A deadbolt includes a body, an insertion member, a roller and a slide. The driving member is connected to the body. The insertion member is received in the body. The second spring biases the insertion member. The slide is restricted by the positioning rods of the driving member and has a first guide pin extending through the first slot. The slide is movable along the first slot. The guide hole includes an extension slot and an inclined slot which inclinedly communicates with the extension slot. When in a non-transmission position, the roller protrudes beyond the receiving space. When in the transmission position, the roller does not protrude beyond the receiving space.