Invention Grant
- Patent Title: Infiltrating immune cell proportions predict anti-TNF response in colon biopsies
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Application No.: US16091988Application Date: 2017-04-06
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Publication No.: US11262358B2Publication Date: 2022-03-01
- Inventor: Shai S. Shen-Orr , Elina Starovetsky , Naama Maimon , Purvesh Khatri , Renaud Gaujoux , Francesco Vallania
- Applicant: Technion Research & Development Foundation Limited , The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: IL Haifa; US CA Stanford
- Assignee: Technion Research & Development Foundation Limited,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: Technion Research & Development Foundation Limited,The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: IL Haifa; US CA Stanford
- International Application: PCT/IL2017/050419 WO 20170406
- International Announcement: WO2017/175228 WO 20171012
- Main IPC: G01N33/569
- IPC: G01N33/569 ; C12Q1/6883 ; G01N33/50 ; C40B30/04
Abstract:
Provided are methods of predicting responsiveness of a subject having an inflammatory bowel disease (IBD) to a tumor necrosis factor (TNF)-alpha inhibitor, by analyzing a frequency of at least one subpopulation of immune cells in a tissue biopsy of the subject. Also provided are methods of selecting a treatment for a subject and kits for determining responsiveness of the subject to treatment with a TNF-alpha inhibitor.
Public/Granted literature
- US20190094223A1 INFILTRATING IMMUNE CELL PROPORTIONS PREDICT ANTI-TNF RESPONSE IN COLON BIOPSIES Public/Granted day:2019-03-28
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