Disclosed are aspects of memory-aware placement in systems that include graphics processing units (GPUs) that are virtual GPU (vGPU) enabled. In some embodiments, a computing environment is monitored to identify graphics processing unit (GPU) data for a plurality of virtual GPU (vGPU) enabled GPUs of the computing environment, a plurality of vGPU requests are received. A respective vGPU request includes a GPU memory requirement. GPU configurations are determined in order to accommodate vGPU requests. The GPU configurations are determined based on an integer linear programming (ILP) vGPU request placement model. Configured vGPU profiles are applied for vGPU enabled GPUs, and vGPUs are created based on the configured vGPU profiles. The vGPU requests are assigned to the vGPUs.