Aspects discussed herein relate to employing deep learning to automate mapping and transformation of a source data set to a target data schema. A system may utilize deep learning algorithms to determine a mapping from the source schema to the target schema through identifying the source schema and creating a correspondence between source fields and target fields, and a corresponding data transformation. Artificial neural networks, configured as schema-level and instance-level classifiers, may generate a set of predictions based on the fields of the source data set and fields of the target data schema. These predictions may be combined with other predictions based on other criteria (such as similarity between the fields) to generate a complete prediction of a schema mapping. Similarly, deep learning techniques may be employed to determine an appropriate data transformation to transform source data content to an appropriate format for corresponding fields of the target schema.