Embodiments of the present disclosure relate to a data driving circuit, a driving method thereof, an array substrate, and a display panel. The data driving circuit includes a data driver, a multiplex circuit, and a control circuit. The data driver includes M data output terminals, and each of the data output terminals provides a data signal to L data lines via the multiplex circuit. The multiplex circuit includes M×L switch groups, and each of the switch groups includes N switch tubes and is coupled between one data line and the corresponding data output terminal. Each switch tube is coupled to one of L×N gate control terminals of the control circuit. Each gate control terminal is coupled to M switch tubes that are spaced apart from each other by (L×N×1) switch tubes. In the embodiments, M is an integer, and L and N are integers greater than or equal to 2.