A power supply protection circuit is a circuit that controls a protection switch provided on a power supply line connecting a direct current power supply and a load circuit. The power supply protection circuit includes: circuitry connected to the protection switch; and a controller that switches an operation state of the circuitry between a first state and a second state. The first state is an operation state in which driving of the protection switch is enabled when the protection switch is a first semiconductor switch having a control terminal connected to a semiconductor layer of a first conductivity type. The second state is an operation state in which driving of the protection switch is enabled when the protection switch is a second semiconductor switch having a control terminal connected to a semiconductor layer of a second conductivity type that is different from the semiconductor layer of a first conductivity type.