An image sensing device includes first to fourth column lines disposed sequentially in a row direction, first and third unit pixel circuits arranged in a first row and coupled to the first and third column lines, respectively, second and fourth unit pixel circuits arranged in a second row and coupled to the second and fourth column lines, respectively, first to fourth readout circuits, a first path change circuit for changing first and second paths so that the first and second unit pixel circuits are coupled to the first and second readout circuits according to a first relationship during a first unit time, and a second path change circuit for changing third and fourth paths so that the third and fourth unit pixel circuits are coupled to the third and fourth readout circuits according to a second relationship during the first unit time.