![Maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, pharmaceutical formulations, methods of manufacture and uses thereof for the treatment of herpes viruses](/docs/US/2022-03-08/US11266636B2/abs.jpg.600x600.jpg)
- Patent Title: Maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, pharmaceutical formulations, methods of manufacture and uses thereof for the treatment of herpes viruses
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Application No.: US16464189Application Date: 2017-11-28
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Publication No.: US11266636B2Publication Date: 2022-03-08
- Inventor: Yogeshwar Bachhav , Wilfried Schwab , Alexander Birkmann , Susanne Bonsmann , Thomas Goldner
- Applicant: AICURIS ANTI-INFECTIVE CURES GMBH
- Applicant Address: DE Wuppertal
- Assignee: AICURIS ANTI-INFECTIVE CURES GMBH
- Current Assignee: AICURIS ANTI-INFECTIVE CURES GMBH
- Current Assignee Address: DE Wuppertal
- Agency: Millen, White, Zelano & Branigan, PC
- Agent Ryan Pool
- Priority: EP16201009 20161128
- International Application: PCT/EP2017/080695 WO 20171128
- International Announcement: WO2018/096177 WO 20180531
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; A61K9/00 ; A61K45/06 ; C07D417/12
![Maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, pharmaceutical formulations, methods of manufacture and uses thereof for the treatment of herpes viruses](/abs-image/US/2022/03/08/US11266636B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to the field of anti-viral active agents, particularly to salts, more particularly to a maleate salt of the free base of N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]-acetamide, to pharmaceutical formulations thereof as well as to methods for the production of these salts. The present invention also relates to the use of theses salts and of respective pharmaceutical formulations thereof in methods of treatment and/or prevention of human herpes simplex virus infections, particularly infections caused by HSV-1 and HSV-2.
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