Invention Grant
- Patent Title: Small molecule inhibitors of HLA-DR3 binding for treating autoimmune thyroiditis
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Application No.: US16063942Application Date: 2016-12-20
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Publication No.: US11266642B2Publication Date: 2022-03-08
- Inventor: Yaron Tomer , Roman Osman
- Applicant: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Applicant Address: US NY New York
- Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
- Current Assignee Address: US NY New York
- Agency: Heslin Rothenberg Farley & Mesiti, P.C.
- International Application: PCT/US2016/067775 WO 20161220
- International Announcement: WO2017/112669 WO 20170629
- Main IPC: A61K31/4725
- IPC: A61K31/4725 ; A61P37/02
Abstract:
A method for treating autoimmune thyroid disease is disclosed. The method comprises administering a molecule of molecular weight below 700 that inhibits the binding of the nonadecapeptide IPDNLFLKSDGRIKYTLNK (SEQ ID NO:1) to HLA-DRβ1-Arg74. Such compounds are found in the class of bisbenzylisoquinoline alkaloids represented by formula I
Public/Granted literature
- US20200281919A1 SMALL MOLECULE INHIBITORS OF HLA-DR3 BINDING FOR TREATING AUTOIMMUNE THYROIDITIS Public/Granted day:2020-09-10
Information query
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