Invention Grant
- Patent Title: Functional prediction of cellular functions by means of microRNA expression profiling in mesenchymal stem cells
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Application No.: US16300249Application Date: 2017-05-09
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Publication No.: US11266687B2Publication Date: 2022-03-08
- Inventor: David Mallinson , Donald Dunbar , Elaine Gourlay , Daria Olijnyk , James Reid
- Applicant: SISTEMIC SCOTLAND LTD
- Applicant Address: GB Glasgow
- Assignee: SISTEMIC SCOTLAND LTD
- Current Assignee: SISTEMIC SCOTLAND LTD
- Current Assignee Address: GB Glasgow
- Agency: Blue Filament Law PLLC
- Priority: GB1608081 20160509,GB1608086 20160509,GB1608497 20160513
- International Application: PCT/EP2017/061096 WO 20170509
- International Announcement: WO2017/194561 WO 20171116
- Main IPC: A61K35/17
- IPC: A61K35/17 ; C12Q1/6883 ; A61P19/00 ; A61P9/00 ; A61P37/06 ; A61P1/00 ; A61P35/00 ; C12N5/0775 ; C12N5/074 ; C12Q1/686

Abstract:
Non-coding RNA, such as miRNA, expression data derived from a cell population is used to infer the propensity of that cell population for a cellular functional effect for a pre-determined purpose, which effect is temporally, procedurally or interventionally separated from the cell population from which the expression data is derived. Thereby, the cellular functional effect of a cell population can be predicted in order to improve decisions and selections to be made relating to the use of cells, e.g. from cells deriving from different donors or batches, for use in bioprocess application or cell therapeutics, in order to enhance productivity, efficiency and/or efficacy.
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