Invention Grant
- Patent Title: Nucleic acids encoding engineered meganucleases with recognition sequences found in the human T cell receptor alpha constant region gene
-
Application No.: US17016056Application Date: 2020-09-09
-
Publication No.: US11266693B2Publication Date: 2022-03-08
- Inventor: Michael G. Nicholson , James Jefferson Smith , Derek Jantz , Victor Bartsevich , Daniel T. MacLeod , Jeyaraj Antony
- Applicant: Precision BioSciences, Inc.
- Applicant Address: US NC Durham
- Assignee: Precision BioSciences, Inc.
- Current Assignee: Precision BioSciences, Inc.
- Current Assignee Address: US NC Durham
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C12N9/22
- IPC: C12N9/22 ; A61K35/17 ; A61K47/66 ; A61K47/65 ; A61P35/00 ; A61K47/42 ; A61K38/00

Abstract:
Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human T cell receptor alpha constant region gene. The present disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells.
Public/Granted literature
Information query