Nucleic acids encoding engineered meganucleases with recognition sequences found in the human T cell receptor alpha constant region gene
Abstract:
Disclosed herein are recombinant meganucleases engineered to recognize and cleave a recognition sequence present in the human T cell receptor alpha constant region gene. The present disclosure further relates to the use of such recombinant meganucleases in methods for producing genetically-modified eukaryotic cells.
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