• Patent Title: Cyclopropyl ring opening by alpha alkylation of an aldehyde with a polycyclic olefin
  • Application No.: US16972081
    Application Date: 2019-10-14
  • Publication No.: US11267776B2
    Publication Date: 2022-03-08
  • Inventor: Julie Quintaine
  • Applicant: FIRMENICH SA
  • Applicant Address: CH Satigny
  • Assignee: FIRMENICH SA
  • Current Assignee: FIRMENICH SA
  • Current Assignee Address: CH Satigny
  • Agency: Armstrong Teasdale LLP
  • Priority: EP18200658 20181016
  • International Application: PCT/EP2019/077791 WO 20191014
  • International Announcement: WO2020/078909 WO 20200423
  • Main IPC: C07C45/68
  • IPC: C07C45/68 C11B9/00 C07C47/225
Cyclopropyl ring opening by alpha alkylation of an aldehyde with a polycyclic olefin
Abstract:
Described herein is a process including alpha alkylation of an aldehyde with a polycyclic olefin followed by a ring opening step in order to provide a compound of formula in a form of any one of its stereoisomers or a mixture thereof and where n represents 1 to 4 and R2 to R5 represent independently of each other, a hydrogen atom or a C1-6 linear alkyl group or a C3-6 branched alkyl group; and R3 and R4 or R5 or, alternatively, R2 and R3 when taken together form a saturated or unsaturated optionally substituted 5 or 6 membered carbocyclic ring.
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