Invention Grant
- Patent Title: Processes for preparing plasma kallikrein inhibitors
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Application No.: US16922080Application Date: 2020-07-07
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Publication No.: US11267790B2Publication Date: 2022-03-08
- Inventor: Sukanto Sinha , Tamie Chilcote , Baburaj Krishnan , Ganapati Bhat , Vineet Malik
- Applicant: Rezolute, Inc. , ActiveSite Pharmaceuticals, Inc.
- Applicant Address: US CA Redwood City; US CA San Francisco
- Assignee: Rezolute, Inc.,ActiveSite Pharmaceuticals, Inc.
- Current Assignee: Rezolute, Inc.,ActiveSite Pharmaceuticals, Inc.
- Current Assignee Address: US CA Redwood City; US CA San Francisco
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- Main IPC: C07D231/14
- IPC: C07D231/14 ; C07D307/68 ; C07D277/56 ; C07D207/34 ; C07D333/38 ; C07D249/04

Abstract:
A process for preparing and purifying a compound of Formula I is provided: or a salt thereof, wherein the subscript m is an integer of from 0 to 3; each Ra is independently selected from the group consisting of (C3-C8)cycloalkyl, (C1-C4)haloalkyl, halogen, —OH, —OR1, —SH, —SR1, —S(O)R1, —S(O)2R1, —SO2NH2, —C(O)NH2, —C(O)NHR1, —C(O)N(R1)2, —C(O)R1, —C(O)H, —CO2R1, —NO2, —NH2, —NHR1, —N(R1)2, wherein each R1 is independently (C1-C8)alkyl; L is a linking group selected from the group consisting of a bond or CH2; Qa, Qb, and Qc are each members independently selected from the group consisting of N, S, O and C(Rq) wherein each Rq is independently selected from the group consisting of H, C1-8 alkyl, halo and phenyl, and the ring having Qa, Qb, Qc and Y as ring vertices is a five-membered ring having two double bonds; and Y is selected from the group consisting of C and N.
Public/Granted literature
- US20210009526A1 PROCESSES FOR PREPARING PLASMA KALLIKREIN INHIBITORS Public/Granted day:2021-01-14
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