Invention Grant
- Patent Title: KRAS G12C inhibitors
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Application No.: US16099398Application Date: 2017-05-17
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Publication No.: US11267812B2Publication Date: 2022-03-08
- Inventor: John P. Fischer , Jay Bradford Fell , James F. Blake , Ronald Jay Hinklin , Macedonio J. Mejia , Erik James Hicken , Mark Joseph Chicarelli , John J. Gaudino , Guy P. A. Vigers , Laurence E. Burgess , Matthew Arnold Marx , James Gail Christensen , Matthew Randolph Lee , Pavel Savechenkov , Henry J. Zecca , Tony P. Tang
- Applicant: Mirati Therapeutics, Inc. , Array BioPharma Inc.
- Applicant Address: US CA San Diego; US CO Boulder
- Assignee: Mirati Therapeutics, Inc.,Array BioPharma Inc.
- Current Assignee: Mirati Therapeutics, Inc.,Array BioPharma Inc.
- Current Assignee Address: US CA San Diego; US CO Boulder
- Agency: Wood, Phillips, Katz, Clark & Mortimer
- International Application: PCT/US2017/033099 WO 20170517
- International Announcement: WO2017/201161 WO 20171123
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D519/00 ; A61P35/00
Abstract:
The present invention relates to compounds that inhibit KRas G12C. In particular, the present invention relates to compounds that irreversibly inhibit the activity of KRas G12C, pharmaceutical compositions comprising the compounds and methods of use therefor.
Public/Granted literature
- US20210269432A1 KRAS G12C INHIBITORS Public/Granted day:2021-09-02
Information query
