Invention Grant
- Patent Title: Class of amino-substituted nitrogen-containing fused ring compounds, preparation method therefor, and use thereof
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Application No.: US16760005Application Date: 2018-10-30
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Publication No.: US11267815B2Publication Date: 2022-03-08
- Inventor: Hui Wang
- Applicant: SHANGHAI RINGENE BIOPHARMA CO., LTD.
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI RINGENE BIOPHARMA CO., LTD.
- Current Assignee: SHANGHAI RINGENE BIOPHARMA CO., LTD.
- Current Assignee Address: CN Shanghai
- Agency: SZDC Law P.C.
- Priority: CN201711039980.6 20171030
- International Application: PCT/CN2018/112661 WO 20181030
- International Announcement: WO2019/085895 WO 20190509
- Main IPC: C07D471/14
- IPC: C07D471/14 ; A61K31/496 ; A61P35/00

Abstract:
The present invention discloses a class of amino-substituted nitrogen-containing fused ring compounds, a preparation method therefor, and a use thereof. The structure of the amino-substituted nitrogen-containing fused ring compounds of the present invention is as shown in formula (I) below, and each group therein is as defined in the specification. The amino-substituted nitrogen-containing fused ring compounds of the present invention are novel specific FGFR kinase inhibitors, having excellent inhibitory activity for FGFR-related tumor cell proliferation, and is applicable to the treatment of diseases such as tumors associated with FGFR kinase mutations or abnormal expressions.
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