Invention Grant
- Patent Title: Variant ActRIIB proteins and uses thereof
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Application No.: US16340048Application Date: 2017-10-05
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Publication No.: US11267865B2Publication Date: 2022-03-08
- Inventor: Ravindra Kumar , Asya Grinberg , Erik M. Vogan
- Applicant: Acceleron Pharma Inc.
- Applicant Address: US MA Cambridge
- Assignee: Acceleron Pharma Inc.
- Current Assignee: Acceleron Pharma Inc.
- Current Assignee Address: US MA Cambridge
- Agency: White & Case LLP
- International Application: PCT/US2017/055421 WO 20171005
- International Announcement: WO2018/067874 WO 20180412
- Main IPC: C07K14/71
- IPC: C07K14/71 ; A61P21/00 ; A61K38/00
Abstract:
In certain aspects, the present invention provides compositions and methods for modulating (promoting or inhibiting) growth of red blood cells or a tissue, such as bone, cartilage, muscle, fat, and/or neuronal tissue. The present invention also provides methods of screening compounds that modulate activity of an ActRIIB protein and/or an ActRIIB ligand. The compositions and methods provided herein are useful in treating diseases associated with abnormal activity of an ActRIIB protein and/or an ActRIIB ligand.
Public/Granted literature
- US20200055919A1 VARIANT ACTRIIB PROTEINS AND USES THEREOF Public/Granted day:2020-02-20
Information query
