Invention Grant
- Patent Title: Anti-transthyretin antibodies
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Application No.: US16753307Application Date: 2018-10-05
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Publication No.: US11267877B2Publication Date: 2022-03-08
- Inventor: Joshua Reginald Salmans , Svetlana Alexander , Robin Barbour , Jeffrey N. Higaki , Tarlochan S. Nijjar
- Applicant: PROTHENA BIOSCIENCES LIMITED
- Applicant Address: IE Dublin
- Assignee: PROTHENA BIOSCIENCES LIMITED
- Current Assignee: PROTHENA BIOSCIENCES LIMITED
- Current Assignee Address: IE Dublin
- Agency: Alston & Bird LLP
- International Application: PCT/US2018/054720 WO 20181005
- International Announcement: WO2019/071205 WO 20190411
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K31/713 ; A61K45/06 ; A61K39/00

Abstract:
The invention provides antibodies that specifically bind to transthyretin (TTR). The antibodies can be used for treating or effecting prophylaxis of diseases or disorders associated with TTR accumulation or accumulation of TTR deposits (e.g., TTR amyloidosis). The antibodies can also be used for diagnosing TTR amyloidosis and inhibiting or reducing aggregation of TTR, and for monitoring the efficacy of TTR therapies, among other applications.
Public/Granted literature
- US20200331992A1 ANTI-TRANSTHYRETIN ANTIBODIES Public/Granted day:2020-10-22
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