Invention Grant
- Patent Title: Method for controlling affinity of antibody for antigen, antibody whose affinity for antigen has been altered, and its production method
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Application No.: US15855508Application Date: 2017-12-27
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Publication No.: US11267904B2Publication Date: 2022-03-08
- Inventor: Shingo Maeta , Atsushi Fukunaga
- Applicant: SYSMEX CORPORATION
- Applicant Address: JP Kobe
- Assignee: SYSMEX CORPORATION
- Current Assignee: SYSMEX CORPORATION
- Current Assignee Address: JP Kobe
- Agency: Sughrue Mion, PLLC
- Priority: JPJP2016-255492 20161228,JPJP2017-155840 20170810
- Main IPC: C07K16/46
- IPC: C07K16/46 ; C07K16/28 ; C07K16/26 ; C07K16/40 ; C07K16/08
Abstract:
Disclosed is a method for controlling affinity of an antibody for an antigen, comprising substituting at least 3 amino acid residues of framework region 3 (FR3) defined by the Chothia method with charged amino acid residues, in an antibody whose electrical characteristic of complementarity determining region (CDR) based on the amino acid sequence of the CDR is neutral or negatively charged.
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