Invention Grant
- Patent Title: Compounds for modulating Fc-epsilon-RI-beta expression and uses thereof
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Application No.: US16052130Application Date: 2018-08-01
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Publication No.: US11268096B2Publication Date: 2022-03-08
- Inventor: Glenn P. Cruse , Dean D. Metcalfe
- Applicant: North Carolina State University , The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US NC Raleigh; US MD Bethesda
- Assignee: North Carolina State University,The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: North Carolina State University,The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US NC Raleigh; US MD Bethesda
- Agency: Jenkins, Wilson, Taylor & Hunt, P.A.
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12N15/113 ; C12N15/11 ; A61K31/7088 ; A61P29/00
Abstract:
Methods for treating diseases and conditions mediated by the high affinity IgE receptor (FcεRI). Antisense oligomers for modulating splicing of mRNA encoding the FcεRIβ protein, thereby down-regulating cell-surface expression of FcεRI, and uses of the antisense oligomers for inhibiting mast cell degranulation, cytokine release, migration, and proliferation.
Public/Granted literature
- US20190062756A1 COMPOUNDS FOR MODULATING FC-EPSILON-RI-BETA EXPRESSION AND USES THEREOF Public/Granted day:2019-02-28
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