Invention Grant
- Patent Title: Assay for safety assessment of therapeutic genetic manipulations, gene therapy vectors and compounds
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Application No.: US15136298Application Date: 2016-04-22
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Publication No.: US11268158B2Publication Date: 2022-03-08
- Inventor: Brian P. Sorrentino , Sheng Zhou
- Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
- Applicant Address: US TN Memphis
- Assignee: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
- Current Assignee: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
- Current Assignee Address: US TN Memphis
- Agency: Troutman Pepper Hamilton Sanders LLP
- Main IPC: C12Q1/70
- IPC: C12Q1/70
Abstract:
The invention is directed to methods of assessing the safety of therapeutic compounds and therapeutic genetic manipulations, including integrating gene therapy vectors and genome editing. In particular, the invention provides a method, wherein the oncogenic potential of therapeutic compounds and therapeutic genetic manipulations, including integrating gene therapy vectors and genome editing, is determined by determining the percentage of differentiation blocked hematopoietic progenitor cells.
Public/Granted literature
- US20160312304A1 ASSAY FOR SAFETY ASSESSMENT OF THERAPEUTIC GENETIC MANIPULATIONS, GENE THERAPY VECTORS AND COMPOUNDS Public/Granted day:2016-10-27
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