A fusible fire-proof emergency cut-off valve is provided. Two sides of a valve body are communicated with an outlet and an inlet, respectively. The inside of the valve body is rotationally connected with a rotating shaft. A valve plate is fixed to one side of the rotating shaft and is positioned at one end of the outlet. A control mechanism comprises a shifting fork box body, one side of the shifting fork box body is connected with a second cylinder, and the other side of the shifting fork box body is connected with a first cylinder. The other side of the rotating shaft is inserted into the shifting fork box body and fixedly connected with a shifting fork. The inside of the second cylinder is provided with a piston rod penetrating through the shifting fork box body and the first cylinder.