Devices and methods for determining one or more analyte concentrations in a sample, determining a sample type, and/or accounting for interference species in a sample are disclosed that include intertwining a first input signal, via a first electrode having a reagent, with a second input signal, via a second electrode lacking a reagent, by applying to the sample the first input signal having at least two excitations and a relaxation, and applying to the sample the second input signal having at least two excitations and a relaxation, such that the excitations of the first input signal are nonconcurrent with the excitations of the second input signal. The method further includes measuring a first output signal responsive to the first input signal and a second output signal responsive to the second input signal.