Embodiments of the present invention may provide systems and methods for self-service configuration management of applications across multiple deployments units, such as computers, servers, and the like. The applications may include software applications, application streams, virtual applications, sandbox applications, and the like. Embodiments of the present invention may create various configuration payloads (e.g., executables) dynamically and in real-time for client machine(s) based on selected configuration changes from a service portal, rather than having each configuration payload being packaged separately and individually by a packager.