The present invention finds and defines a problem which possibly exists in an interrupt remapping mechanism under a virtual symmetric multiprocessing environment, i.e., a problem of Interruptability Holder Preemption (IHP). This problem causes the interrupt remapping mechanism to fail and reduces I/O performance of virtual machines. In order to solve the IHP problem, the present invention provides a proactive VCPU comprehensive scheduling method based on interruptability holder information. This method is based on Kernel-Based Virtual Machines (KVMs) which are widely used at present and paravirtualization network models thereof. By globally controlling and analyzing a running state of an interruptability holder and simultaneously considering global scheduling fairness of a system, a VCPU comprehensive scheduling method is established, which can effectively eliminate the IHP problem and obviously improve the I/O performance of the virtual machines.