Distributed transactions are performed over a collection of servers operating as replicas of a data set, where a successful transaction involves meeting a quorum count of replicas that locally commit the transaction. However, performance constraints of data sets and consuming applications may vary (e.g., sensitivity to latency, scalability, and/or consistency), and the performance characteristics of the server set may be partly determined by the transactional commitment and quorum selection. The distributed transaction may be applied by designating the replicas as a set of followers and a leader that initiates the transaction and receives acknowledgments of local commits by each follower. On condition of the acknowledgments meeting a quorum count for the data set according to the performance characteristics of the application, the leader locally commits the transaction and delivers a result. The transaction may also be applied over collections of replica sets using a second-level quorum to achieve nested consensus.