A processing node in a temporal memory system includes a spatial pooler and a sequence processor. The spatial pooler generates a spatial pooler signal representing similarity between received spatial patterns in an input signal and stored co-occurrence patterns. The spatial pooler signal is represented by a combination of elements that are active or inactive. Each co-occurrence pattern is mapped to different subsets of elements of an input signal. The spatial pooler signal is fed to a sequence processor receiving and processed to learn, recognize and predict temporal sequences in the input signal. The sequence processor includes one or more columns, each column including one or more cells. A subset of columns may be selected by the spatial pooler signal, causing one or more cells in these columns to activate.