Embodiments of the present disclosure relate to a method and apparatus for waking up a device. The method may include: collecting an audio signal in an environment the device located therein; determining, in response to that the audio signal includes a custom wake-up word being determined, a response strategy preset by a user and corresponding to the custom wake-up word; determining a target response text based on the response strategy; and generating a response speech of the target response text and playing the response speech.