Disclosed is a waterseal virus-killing mask, including a mask body, a liquid virus-killing assembly, and two elastic ear loops. A breather valve is disposed on an outer surface of the mask body. The two elastic ear loops are disposed on two sides of the mask body, respectively. The liquid virus-killing assembly includes a U-shaped tube within which disinfectant is provided. A disinfectant replenishing tube is vertically disposed at an upper end in the middle of the U-shaped tube. A first horizontal straight tube and a second horizontal straight tube are separately disposed at two ends of the U-shaped tube. A left end of the first horizontal straight tube is in communication with an opening of the breather valve. A first filter mesh used to separate water and air is disposed at a right end of the first horizontal straight tube.