Invention Grant
- Patent Title: TRPV1 modulator compounds
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Application No.: US16608841Application Date: 2018-05-10
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Publication No.: US11274073B2Publication Date: 2022-03-15
- Inventor: Isabel Devesa Giner , Armando Genazzani , Tracey Pirali , Asia Fernandez Carvajal , Antonio Vicente Ferrer Montiel
- Applicant: ANTALGENICS, S.L.
- Applicant Address: ES Elche
- Assignee: ANTALGENICS, S.L.
- Current Assignee: ANTALGENICS, S.L.
- Current Assignee Address: ES Elche
- Agency: Squire Patton Boggs (US) LLP
- Priority: EP17382266 20170511
- International Application: PCT/EP2018/062169 WO 20180510
- International Announcement: WO2018/206742 WO 20181115
- Main IPC: C07C235/08
- IPC: C07C235/08 ; C07C231/06 ; A61P29/00 ; A61P17/04

Abstract:
The present invention relates to TRPV1 modulator compounds of formula (I) or their pharmaceutically, veterinary or cosmetically acceptable salts, or their stereoisomers or mixtures thereof, wherein m is an integer selected from 1 to 3; R1, R2, R6 and R6′ are independently selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, and (C3-C6)cycloalkyl, being these groups optionally substituted; R3 is hydrogen or halogen; R4 is selected from H, (C1-C8)alkyl, unsaturated (C2-C8)hydrocarbon, (C3-C6)cycloalkyl, (C6-C12)aryl, and (C5-C12)heteroaryl, being these groups optionally substituted; and R5 is selected from (C3-C28)alkyl, unsaturated (C3-C28)hydrocarbon, (C6-C12)aryl, and (C5-C12)heteroaryl, being these groups optionally substituted. It also relates to a process for their preparation, to pharmaceutical, veterinary or cosmetic compositions containing them, and to their pharmaceutical, veterinary and cosmetic applications.
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